与压力相关的神经网络活动的减少调解了酒精对心血管风险的影响
Kenechukwu Mezue1, Michael T Osborne2, Shady Abohashem2
1Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Journal of the American College of Cardiology
|June 14, 2023
概括
轻度到中度的酒精消费与较少的重大心血管不良事件 (MACE) 相关,因为它减少了与压力相关的神经网络活动 (SNA). 这项研究表明,SNA减少是酒精的关键机制.
科学领域:
- 心血管疾病的研究研究.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 慢性压力通过增加与压力相关的神经网络活动 (SNA) 来提高主要不良心血管事件 (MACE) 的风险.
- 轻度/中度酒精消费 (ACl/m) 显示了与降低MACE风险的潜在关联,但潜在的机制仍然不清楚.
研究的目的:
- 调查是否降低SNA调解了轻度/中度饮酒 (ACl/m) 和降低MACE风险之间的关联.
- 探索与压力相关的神经网络在适度饮酒对心血管健康的益处中的作用.
主要方法:
- 分析了来自美国大众医院布里格姆生物银行 (Mass General Brigham Biobank) 的数据,包括健康行为调查和用于SNA评估的F-氧葡萄糖正子发射断层扫描.
- 酒精消费的分类:没有/最小,轻度/中度,高度.
- 统计分析以确定ACl/m,SNA和MACE之间的关联,包括调解分析.
主要成果:
- 轻度/中度饮酒 (ACl/m) 与MACE风险显著降低相关 (HR:0.786;P < 0.0001).
- 在接受脑成像的参与者中,ACl/m与与压力相关的神经网络活动 (SNA) 的降低有关 (标准化β: -0.192;P = 0.01).
- 减少的SNA部分调解了ACl/m对MACE的保护作用 (log OR: -0.040; P <0.05),在先前焦虑的人群中观察到更强的效果.
结论:
- 轻度/中度饮酒 (ACl/m) 与心血管重大不良事件 (MACE) 的风险降低有关,部分原因是通过减少与压力相关的神经网络的活动.
- 这些发现强调了压力途径在心血管健康中的作用,并提出了新的干预措施的潜在目标,考虑到已知的酒精对健康的不利影响.
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