孕产妇压力对死角 enterokolitis 的发展的影响:一个全面的审查
Riadh Cheddadi1, Nitika Narendra Khandekar2, Venkata Yeramilli1
1Department of Surgery, Division of Pediatric Surgery, Children's of Alabama, University of Alabama at Birmingham, 1600 7th Ave. S., Lowder Building Suite 300, Birmingham, AL 35233, United States.
Seminars in pediatric surgery
|June 14, 2023
概括
怀孕期间母亲的压力可能会增加婴儿患死角性肠球炎 (NEC) 的风险. 这篇评论探讨了母亲的压力,NEC预测因素和动物模型,以了解这种联系.
科学领域:
- 新生儿医学 新生儿医学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 胃肠病学 胃肠病学
背景情况:
- 结核性肠球炎 (NEC) 是新生儿的一种严重的肠道疾病,其特点是患病率和死亡率高.
- 虽然存在许多NEC预测因素,但母亲的因素,特别是怀孕期间的压力,尚未得到充分探索.
- 孕期引起的母亲的生理和心理压力可能会对胎儿的发育和健康产生负面影响.
研究的目的:
- 调查怀孕期间母亲的压力与新生儿中NEC的发展之间的联系.
- 审查NEC的已知预测因素和风险因素.
- 检查用于研究产前压力对后代影响的动物模型.
主要方法:
- 文献综述综合了关于母亲压力,NEC和产前影响的当前研究.
- 对生理和心理路径的分析,将母亲的压力与新生儿的结果联系起来.
- 已确定的NEC风险因素的总结和与新出现的孕产妇压力假设的比较.
- 评估动物模型在研究产前压力和NEC时的有用性.
主要成果:
- 母亲的压力可以诱导系统性变化,这可能会使新生儿易患NEC.
- 动物研究表明,母亲的压力与后代的NEC状况之间存在相关性.
- 现有的NEC风险因素不能完全解释疾病发病率,突出了对母性因素的需求.
结论:
- 孕产妇的压力是NEC病变发生的潜在重要,被低估的因素.
- 对母亲的压力及其对胎儿发育的影响进行进一步的研究对于预防NEC至关重要.
- 了解这些联系可以为减轻脆弱新生儿NEC风险的干预提供信息.
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