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系统性类固醇使用是否会影响头感染住院时间?
Joanna Sajdlowska1, Kevin Francois2, Steven Halepas3
1Department of General Surgery, St. Joseph's University Medical Center, Paterson, NJ, USA.
对头部感染的全身类固醇在住院期间显示出混合的结果. 数据不足阻止了元分析,需要进一步的研究,特别是随机对照试验.
科学领域:
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 头部感染是常见的疾病,需要有效的治疗.
- 系统性类固醇有时用于管理这些感染中的炎症和症状.
- 对于类固醇在头部和部感染中的疗效的证据基础需要进一步澄清.
研究的目的:
- 进行系统审查和元分析.
- 为了研究用全身类固醇治疗头部感染的结果.
主要方法:
- 从PubMed/Medline开始到2021年8月的系统文献搜索.
- 包括队列和/或横截面研究,将全身类固醇治疗与对照组进行比较.
- 提取关于逗留时间和统计学意义的数据.
主要成果:
- 三项研究符合纳入标准,数据可用性各不相同.
- 两项研究表明,使用类固醇可以减少停留时间.
- 一项较大的研究报告说,在使用类固醇时,停留时间增加.
结论:
- 现有的数据不足以进行元分析.
- 在头部和部感染中使用类固醇对逗留时间有相互矛盾的影响.
- 未来的随机对照试验对于指导基于证据的实践至关重要.
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