从0岁到4岁的人类头骨面部正常生长和发育
Ce Liang1, Antonio Profico2, Costantino Buzi3,4
1Department of Mechanical Engineering, University College London, London, UK.
Scientific reports
|June 14, 2023
概括
人类面生长在生命的第一年表现出快速的变化,部发育显著. 在前48个月内,在整体头骨形状上没有观察到任何显著的性别差异.
科学领域:
- 面生物学 面生物学
- 发育生物学是发展生物学.
- 医学成像医学成像
背景情况:
- 了解人类面生长和发育对于治疗相关临床疾病至关重要.
- 早期儿童发育涉及骨大小,形状和相关软组织的复杂变化.
研究的目的:
- 通过使用临床CT扫描来研究头面部生长和发育在生命的前48个月.
- 详细说明头骨形状的性别特异性变化及其与软组织发育和鼻腔扩张的关联.
- 为人类面生长和发育开发一个统一的模型.
主要方法:
- 使用3D地标和半地标的形状的多变量分析.
- 从广泛的临床CT扫描数据中分析线性尺寸和体积.
- 在生命的前48个月中,对性别之间的面变化的比较分析.
主要成果:
- 头骨形状的变化在整个幼儿时期呈现加速和减速.
- 较大的形变化发生在0-12个月之间,而12-48个月.
- 在研究的年龄段中,在整体头骨形状发育中没有发现显著的性二态.
结论:
- 为了未来的研究,提出了人类面生长和发育的单一模型.
- 这些发现提供了对控制面发育的物理机械相互作用的见解.
- 这项研究有助于更好地了解早期儿童的正常面发育.
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