在急性重度高血压患者访问急诊室的D-二次体和长期死亡率之间存在关联
Byung Sik Kim1, Jeong-Hun Shin2
1Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Hanyang University Guri Hospital, 153 Gyeongchun-Ro, Guri, Gyeonggi-Do, 11923, Republic of Korea.
Clinical hypertension
|June 14, 2023
概括
在急性严重高血压患者中,D-二聚物水平升高显著增加了3年死亡风险. 这一发现表明,D-二聚合物是这个患者群体的有价值的预后标记物.
科学领域:
- 心脏病学 心脏病学
- 紧急医疗 紧急医疗
- 血栓形成研究研究
背景情况:
- D-二聚体表明血栓事件,并与心血管疾病的不良结果有关.
- 在急性重度高血压中,D-二聚物的预后影响仍未得到充分研究.
研究的目的:
- 调查急性严重高血压患者的D-二聚物水平与长期死亡率之间的关联.
- 为了确定D-二次体是否可以在这个人群中作为预后标记物.
主要方法:
- 对4127名急性严重高血压 (SBP ≥180 mmHg或DBP ≥100 mmHg) 患者的观察研究,这些患者被送往急诊室.
- 根据D-二次体水平,患者被分为三次体.
- 在3年的随访期内评估了所有原因的死亡率.
主要成果:
- 三年死亡率为3.1% (最低三位数),17.0% (第二三位数) 和43.2% (最高三位数) 的D-二次数水平.
- 经过对混因子进行调整后,D-二次体的最高和第二次三次体显示出与最低三次体相比,所有原因死亡率的风险显著增加 (分别为HR 6.440和2.847).
结论:
- 在急性重症高血压患者中,D-二聚物水平与长期死亡率的增加密切相关.
- 在急诊室的急性重度高血压患者中,D-二次体可能作为风险分层的有价值的预后生物标志物.
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