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在随机化试验中评估治疗效果异质性的样本大小考虑,具有异质的集群内相关性和差异

Guangyu Tong1, Monica Taljaard2,3, Fan Li1,4

  • 1Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.

Statistics in medicine
|June 14, 2023
PubMed
概括

新的样本大小公式有助于研究人员在评估治疗效果修改时准确确定集群随机试验和个别随机组治疗试验所需的参与者数量. 这些公式考虑了研究手臂之间的结果变异和集群内相关系数 (ICC) 的变化.

关键词:
双臂之间的异质性集群随机试验是指一个集群随机试验.治疗效果的异质性 治疗效果的异质性个别随机组治疗试验是个别随机组治疗试验.集群内部相关系数的相关系数部分嵌套设计部分嵌套设计

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