社会游戏行为以特定区域的方式塑造前额抑制的发展
Ate Bijlsma1,2, Louk J M J Vanderschuren1, Corette J Wierenga2,3
1Department of Population Health Sciences, Section Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands.
Cerebral cortex (New York, N.Y. : 1991)
|June 15, 2023
概括
社交游戏塑造了大脑的发展. 游戏剥夺减少了抑制性的,而不是刺激性的神经传递,在老鼠前额叶皮层区域不同,揭示了不同的发育时间表.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 行为神经科学 行为神经科学
背景情况:
- 通过经验,神经元连接得到了改进,这对大脑发育至关重要.
- 社会游戏行为显著影响大鼠中介前额叶皮层中的抑制性突触发育.
- 社交游戏对前额叶皮层发育的影响的时间和区域特异性仍然不清楚.
研究的目的:
- 调查社交游戏对大鼠中介前额皮层 (mPFC) 和轨道前额皮层 (OFC) 激发性和抑制性神经传递的影响的时间和区域异质性.
主要方法:
- 在出生后几天 (P21),P42和P85.5的老鼠5层金字塔神经元的电生理记录.
- 在P21和P42之间实施了社交游戏剥夺.
- 在不同发育阶段和前额子子区域的游戏剥夺和对照组之间的刺激和抑制突触电流的比较.
主要成果:
- 在P21上,OFC表现出比mPFC更高的刺激和抑制突触输入.
- 剥夺社交游戏并没有改变刺激性神经传递.
- 在mPFC和OFC中,社交游戏剥夺减少了抑制性传播,与特定区域的时间:减少发生在mPFC中剥夺期间,但在OFC中表现为剥夺后.
结论:
- 社交游戏体验以特定区域的方式影响大鼠前额叶皮层内抑制性神经传递的发展.
- mPFC和OFC的发展轨迹在它们对社交游戏体验的敏感度上有所不同.
- 这些发现突出了社会经验和前额外子区域的独特发展时间表之间的复杂相互作用.
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