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腹腔外科手术后肠道微生物组和相关代谢物和与健康对照者的比较
Adilah F Ahmad1,2, Jose A Caparrós-Martín3, Silvia Lee1,2,4
1Medical School, The University of Western Australia, Perth 6009, Australia.
Microorganisms
|June 15, 2023
概括
与健康人相比,肥胖患者表现出改变的肠道细菌和更高的酸盐水平在腹手术前后. 这些肠道微生物组的变化,包括特定的细菌丰富和减少,在袖子胃切除术后持续存在.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 肥胖研究的研究.
背景情况:
- 肠道微生物群影响宿主脂肪储存和肥胖的发展.
- 减肥手术是对肥胖的常见治疗方法.
研究的目的:
- 为了比较肠道微生物分类概况和相关代谢物在接受袖子胃切除术的肥胖患者与健康的对照组.
- 为了研究在袖子胃切除术前和6个月后肠道微生物组的变化.
主要方法:
- 对接受袖子胃切除术的肥胖成年人进行观察性队列研究.
- 对微生物分类学概况和血代谢物的分析.
- 与健康的对照组进行比较.
主要成果:
- 在肥胖患者 (手术前和手术后) 和健康对照人群之间,没有发现肠道细菌多样性的显著差异.
- 与对照人群相比,肥胖患者在*Granulicatella* (基线),*Streptococcus*和*Actinomyces* (随访) 中表现出丰富.
- 在肥胖患者中观察到,开始性克洛斯特里迪亚的丰度降低和血乙酸盐水平升高.
- 在手术前的肥胖患者中发现了更高的可溶性CD14和CD163水平.
结论:
- 与健康对照人群相比,肥胖个体表现出明显的肠道微生物组变化,即使没有多样性差异.
- 这些微生物变化,包括特定的细菌群丰度和代谢物水平,存在于袖子胃切除术之前,并在袖子胃切除术后持续存在.
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