肠道微生态变化与动脉血症之间的关联
Xinyu Zhuo1, Hui Luo1,2, Rumei Lei1
1Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Wenzhou Road, Gongshu District, Hangzhou 310000, China.
Microorganisms
|June 15, 2023
概括
肠道微生态显著影响动脉样硬化 (AS),这是心血管疾病 (CVD) 的主要原因. 肠道细菌及其代谢物的不平衡有助于AS的发展和进展.
科学领域:
- 心血管科学 心血管科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 动脉样硬化 (AS) 是一种慢性炎症性动脉疾病,是心血管疾病 (CVD) 死亡的主要原因.
- 阿斯病原包括脂质透,内皮功能障碍和慢性炎症.
- 新兴研究强调了肠道微生态疾病在AS发展中的关键作用.
研究的目的:
- 审查肠道微生态与动脉样硬化之间的复杂关系.
- 探索肠道细菌及其代谢物如何影响AS.
- 根据肠道健康来确定AS的潜在治疗点.
主要方法:
- 对调查肠-AS轴的研究进行文献综述.
- 分析将肠道微生物群,脂聚糖 (LPS),三甲基胺N氧化物 (TMAO),短链脂肪酸 (SCFA) 和胆酸代谢与AS联系起来的机制.
- 对肠道微生态平衡对AS的影响进行当前研究的综合.
主要成果:
- 肠道G细菌脂多糖 (LPS) 通过触发炎症反应来促进AS.
- 细菌代谢物如三甲基胺N氧化物 (TMAO) 和短链脂肪酸 (SCFA) 影响脂质代谢和血压,影响AS.
- 肠道微生态中的干扰会干扰胆酸代谢,加剧AS的进展.
结论:
- 保持平衡的肠道微生态对于预防和治疗动脉样硬化至关重要.
- 准肠道微生物组及其代谢物为AS提供了一个有前途的治疗策略.
- 对肠动脉交叉的进一步研究对于推进AS治疗至关重要.
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