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慢性肝炎E病毒感染的诊断,病理生理学和治疗 - 一种影响免疫功能低下患者的疾病

Satoshi Takakusagi¹, Satoru Kakizaki², Hitoshi Takagi¹

¹Department of Gastroenterology and Hepatology, Kusunoki Hospital, 607-22 Fujioka, Fujioka 375-0024, Gunma, Japan.

|June 15, 2023

概括

肝炎E病毒 (HEV) 可以导致慢性肝炎 (CHE),特别是在免疫功能低下的人群中. 早期诊断和利巴维林治疗对于预防肝损伤和减少全球肝炎相关死亡至关重要.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
免疫学免疫学免疫学

背景情况:

肝炎E病毒 (HEV) 导致动物感染,全球每年估计有2000万例病例.
虽然HEV往往是自我限制的,但可以导致慢性肝炎 (CHE),特别是在像移植接收者这样的免疫受损患者中.
最近的报道表明,在艾滋病毒,恶性瘤,类风湿性疾病和COVID-19患者中,CHE.

研究的目的:

提供关于E型肝炎的概述,重点关注慢性E型肝炎 (CHE) 最近的发展.
提高对CHE诊断和管理的理解,特别是在高危人群中.
强调早期检测和治疗的重要性,以预防严重的肝脏并发症.

主要方法:

审查有关HEV感染和慢性肝炎E的现有文献.
分析免疫功能低下,抗体反应较低的患者的诊断挑战.
讨论治疗策略,包括利巴维林治疗.

主要成果:

在各种免疫受损群体中,越来越多地发现了CHE,包括移植接受者,艾滋病毒患者和接受化疗的人.
基于抗体的标准诊断可能会因为抗体反应低而导致免疫受损的个体失败.
在高危患者中,HEV RNA检测对于诊断CHE至关重要.

结论:

通过HEV RNA测试早期诊断CHE对于有效管理至关重要.
及时治疗,可能使用利巴维林,可以预防肝硬化或肝衰竭的进展.
意识到CHE,即使在罕见的免疫不良病例中,也是必要的,以减少全球肝炎相关的死亡率.

关键词:

这是一种HEVRNA.慢性肝炎E 慢性肝炎E 的病例.具有免疫能力的免疫能力.免疫性受损的人.病变的发生和发病.利巴维林是一种利巴维林.

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