尿液分子生物标记测试影响前列腺活检临床实践中的决策
Neal Shore1, Jason Hafron2, Timothy Langford3
1Carolina Urologic Research Center, Myrtle Beach, South Carolina.
Urology practice
|June 15, 2023
概括
SelectMDx尿检显著影响前列腺活检决策. 积极的结果导致活检的数量增加了五倍,有助于检测临床上显著的前列腺癌.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 分子诊断学 分子诊断
- 在瘤学瘤学.
背景情况:
- 需要使用非侵入性方法来识别患有临床显著前列腺癌高风险的患者.
- SelectMDx是一种经过验证的分子尿液测试,用于检测格里森评分7+癌症 (ISUP等级组2-5).
研究的目的:
- 评估SelectMDx测试对社区泌尿外科实践中前列腺活检决策的影响.
- 在现实环境中评估测试的临床实用性.
主要方法:
- 一个多中心试验,涉及5个美国泌尿外科实践.
- 招募了418名正在接受初始前列腺活检评估的患者.
- 在SelectMDx阳性和阴性结果之间比较了活检和前列腺癌检测率.
主要成果:
- 61%的患者有SelectMDx负面结果,39%的患者有积极结果.
- 活检率为阳性结果的60%,为负面结果的12% (p <0.001).
- 癌症,包括大于等级组2的癌症,在43%的活检阳性病例中被发现.
结论:
- SelectMDx在临床实践中显著影响了前列腺活检决策.
- 该测试通过增加阳性病例的活检率,证明了实质性的临床效用.
- 现实世界的数据支持SelectMDx在管理前列腺癌评估患者中的作用.
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