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Updated: Jul 26, 2025

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
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在怀孕期间使用以生理学为基础的药物动力学建模用于通过肝脏清除的药物:监管视角

Paola Coppola1, Essam Kerwash1, Susan Cole1

  • 1Medicines and Healthcare Products Regulatory Agency (MHRA), London, UK.

Journal of clinical pharmacology
|June 15, 2023
PubMed
概括

基于生理学的药物动力学建模表明,预测怀孕期间药物暴露的变化是有前途的. 然而,目前的模型需要进一步改进,以准确地捕捉孕妇的药物代谢和暴露.

关键词:
药物动力学 药物动力学基于生理学的药物动力学建模.怀孕 PBPKK 的怀孕情况怀孕期间的药理动力学监管部门的监管机构.

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