相关实验视频

Updated: Jul 26, 2025

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

在老鼠中,因弗利克西马布对amycin诱导的耳毒性有保护作用

Pelin Koçdor, Esra Özkan¹, Fatmanur Akpunar¹

¹Koç University Research Center for Translational Medicine, Istanbul.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

|June 15, 2023

概括

在小鼠中,因弗利克西马布 (INF) 保护了对卡纳米辛 (KM) 引起的听力损失,特别是在较低剂量时. 基于瘤坏死因子的炎症与KM耳毒性有关.

科学领域:

耳毒性研究研究
听力损失的药理学听力损失的药理学
炎症和细胞损伤的发生.

背景情况:

瘤坏死因子-α (TNF-α) 阻断剂可以减轻炎症反应和细胞死亡.
了解炎症在药物引起的听力损失中的作用至关重要.

研究的目的:

调查因弗利克西马布 (INF) 保护性有效性,以防止卡纳米辛 (KM) 诱导的耳毒性.
探索TNF-α在卡纳米辛引起的听力损伤中的作用.

主要方法:

鼠被分为两组,分别接受不同剂量的KM,INF或甲基prednisolone (MP).
听觉脑干反应 (ABR) 用于评估听力值.
对耳组织进行了分析,检测出血管区域,螺旋性质神经元,毛细胞光,后突触密度 (PSD) 和前突触带 (PSR).

主要成果:

卡纳米辛在第14天显著增加了听力值.
在与低剂量KM一起使用时,infliximab保留了听力和耳结构 (毛细胞,PSD,PSR).
与对照组相比,甲基prednisolone治疗导致头发细胞光和突触结构显著降低.

结论:

瘤缩因子驱动的炎症似乎是胺诱导的耳毒性机制的一个关键因素.
因弗利克西马布显示出作为一种保护性剂的潜力,可以预防某些类型的药物诱导性听力损失.

更多相关视频

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection

Published on: March 28, 2012

相关概念视频

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...