乳腺癌患者的受控卵巢过度刺激:雌激素受体状态是否有所不同?
Stephanie Sii1, Alex Polyakov2, Genia Rozen2
1Newlife IVF, Melbourne, Victoria, Australia.
概括
雌激素受体 (ER) 阳性乳腺癌的女性表现出改善的卵巢刺激结果,包括更多的卵细胞被结,尽管年龄较大. 这表明ER状态可能会影响乳腺癌患者的生育保存成功.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 在生育能力上.
背景情况:
- 乳腺癌受体状态,特别是雌激素受体 (ER) 状态,可能会影响卵巢刺激的结果,以保持生育能力.
- 了解这些关联对于指导年轻癌症患者的治疗决策至关重要.
研究的目的:
- 研究乳腺癌患者的ER状态与其生育保护结果之间的关系.
- 为了比较ER阳性和ER阴性乳腺癌患者之间的卵巢刺激参数和实验室结果.
主要方法:
- 一项回顾性研究包括了214名在2008年至2018年期间被诊断患有乳腺癌的妇女,她们接受了生育保护.
- 收集的数据包括患者年龄,卵巢刺激参数 (例如FSH剂量,持续时间) 和实验室结果 (冷卵细胞和胚胎).
- 结果在ER阳性和ER负组之间进行了比较.
主要成果:
- 与ER阴性患者 (n=70) 相比,ER阳性患者 (n=131) 的冷卵子细胞平均数量显著高 (12.4对9.2,P=0.03),尽管年龄较大 (35.0对33.4年,P=0.03).
- 群体之间在卵泡刺激激素剂量,刺激持续时间,收集的成熟卵细胞或冷胚胎方面没有发现显著差异.
- 生育保存方法包括卵细胞冷 (n=131),胚胎冷 (n=70) 和组合方法 (n=13).
结论:
- 雌激素受体阳性乳腺癌患者可能会经历更有利的卵巢刺激结果,以保持生育能力.
- 这些发现表明,ER状态在乳腺癌幸存者的生育保护周期期间可能对卵细胞产量产生影响.
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