在COVID-19患者的骨髓血液形成
Ewerton Marques-Maggio1,2, Umberto Maccio1, Alexandra Marx3
1Department of Pathology and Molecular Pathology, University Hospital of Zurich, University of Zurich, Zürich, Switzerland.
Histopathology
|June 15, 2023
概括
严重的冠状病毒疾病2019 (COVID-19) 影响骨髓,导致血细胞生产的变化和红细胞分解的增加. 这项研究没有发现SARS-CoV-2在骨髓中复制的证据.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 严重急性呼吸道综合征冠状病毒2型 (SARS-CoV-2) 感染会破坏器官恒温,包括造血系统.
- 尸体解剖研究对于了解2019年严重冠状病毒病 (COVID-19) 中的特定器官病理至关重要.
研究的目的:
- 分析严重的COVID-19对骨髓血液形成的影响.
- 为了将骨髓发现与临床和实验室参数相关联.
- 为了调查SARS-CoV-2在骨髓中的存在.
主要方法:
- 对28例尸体解剖病例和5例对照病例的分析.
- 骨髓病理学和微观环境的全面检查.
- 在骨髓中检测SARS-CoV-2的定量聚合酶连锁反应 (qPCR).
主要成果:
- COVID-19患者表现出改变的骨髓构造,增加的骨髓状腺与红细胞状腺的比率,以及巨核构造.
- 观察到频繁的红细胞 (54%) 和 siderophages (73%),与较低的血红蛋白相关.
- 发现CD68+巨细胞增加;SARS-CoV-2在骨髓中没有检测到.
结论:
- SARS-CoV-2 感染间接影响血液构造区和骨髓免疫微环境.
- 红细胞瘤是严重的COVID-19中常见的发现,与降低的血红蛋白水平有关.
- 骨髓不是SARS-CoV-2复制的常见地点.
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