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Updated: Jul 26, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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C9orf72 蛋白质质量控制由UBR5介导的异型无素链

Julia Jülg1, Dieter Edbauer1,2, Christian Behrends1

  • 1Munich Cluster for Systems Neurology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.

EMBO reports
|June 15, 2023
PubMed
概括

C9orf72-SMCR8复合体对于预防神经退行性疾病至关重要. SMCR8保护C9orf72蛋白免受降解,为肌缩侧面硬化症和前性痴呆症提供潜在的治疗点.

关键词:
在BAG6复合体中,C9orf7272 是一个很好的方法.与K11/K48相关联的无素.这就是UBR5 UBR5的特性.不同类型的ubiquitin链.

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