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口服输送可变胆红素自组装系统用于肠炎的向治疗

Zhejie Chen¹, Yi Chen¹, Wei Hao¹

¹Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China.

Advanced healthcare materials

|June 15, 2023

概括

丁硫酸盐有助于产生胆红素自组装纳米药物 (BSNM) 用于性结肠炎 (UC) 治疗. 这种针对结肠的BSNM有效地减少了炎症并恢复了肠道健康.

科学领域:

生物医学工程生物医学工程
纳米医学是一种纳米医学.
胃肠病学胃肠病学

背景情况:

性结肠炎 (UC) 是一种慢性炎症性结肠疾病,治疗选择有限.
胆红素 (BR) 具有抗氧化和抗结肠病性质,但由于水不溶性,在配方方面面临挑战.
目前基于BR的疗法往往涉及复杂的合成,造成发展障碍.

研究的目的:

开发一种新型,自组装的纳米药物,用于使用比利鲁宾的性结肠炎向治疗.
为了克服与胆红素水不可溶性相关的配方挑战.
在UC的临床前模型中评估开发的纳米药物的治疗疗效.

主要方法:

对材料的选,以识别氏丁硫酸盐作为胆红素自我组装的媒介.
利用硫酸和胆红素之间的分子间键形成自组装纳米药物 (BSNM).
描述BSNM的pH值和反应性氧物种对目标结肠输送的反应性.

主要成果:

BSNM 证明了 pH 和 ROS 的响应性,使得可针对性地输送到结肠.
口服BSNM显著抑制了结肠纤维化,亡和炎症性细胞因子表达.
BSNM保持了肠道屏障的完整性,调节了巨细胞的两极分化,并促进了肠道菌群的恢复.

结论:

一种简单的,针对结肠的,可转换的胆红素自组装纳米药物 (BSNM) 已成功制备.
作为性结肠炎的有效向治疗方法,BSNM显示出显著的治疗潜力.
这种方法为克服配方问题和提高自然抗氧化剂在治疗炎症性肠道疾病中的有效性提供了一个有希望的策略.

关键词:

胆红素是什么意思胆红素是什么意思顺德里二硫酸盐顺德里二硫酸盐分子间的键是分子间的键.自组装系统自组装系统性结肠炎是一种

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