基于植物的生物制药工程
Lukas Eidenberger1, Benjamin Kogelmann1,2, Herta Steinkellner1
1Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Nature reviews bioengineering
|June 15, 2023
概括
分子农业使用工程植物生产治疗性蛋白质和疫苗. 这项技术提供了成本优势和快速部署,但需要解决广泛使用的监管障碍.
科学领域:
- 生物技术是生物技术.
- 植物科学 植物科学
- 制药生产 制药生产
背景情况:
- 植物可以通过基因工程进行重组蛋白质生产,称为分子农业.
- 这种方法为生物制药的快速,全球部署提供了潜力,其冷链需求最小,增强了公平的获取.
- 目前的基于植物的工程利用遗传电路来实现复杂蛋白质的高通量表达.
研究的目的:
- 审查生物制药生产的基于植物的工程战略.
- 讨论表达系统,宿主选择和向量设计,用于在植物中产生复杂的蛋白质.
- 突出翻译后修改工程和特定植物生物制品的进步.
主要方法:
- 关于植物生物制药生产的当前文献的综述.
- 讨论表达宿主 (例如,Nicotiana benthamiana),病毒元素和短暂的表达载体.
- 检查用于翻译后修改和产生单克隆抗体和纳米粒子的工程策略.
主要成果:
- 与哺乳动物系统相比,植物分子农业证明了具有成本效益的生物制药生产潜力.
- 已经成功地实现了复杂生物制剂的植物性表达,如单克隆抗体和病毒样颗粒.
- 技术经济分析表明,植物性蛋白质生产具有成本优势.
结论:
- 植物分子农业是生产高质量的生物制药的有希望的平台.
- 工程遗传电路和优化表达系统是成功分子农业的关键.
- 解决监管挑战对于植物生物制药的广泛采用至关重要.
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