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Updated: Jul 26, 2025

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Granulocyte-dependent Autoantibody-induced Skin Blistering
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患有自身免疫性斗牛性疾病的患者中COVID-19的结果
Dipankar De1, Raihan Ashraf1, Hitaishi Mehta1
1Department of Dermatology Venereology & Leprology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Indian journal of dermatology, venereology and leprology
|June 15, 2023
概括
接受Rituximab治疗的自身免疫球状疾病患者患COVID-19感染的风险更高. 高龄,活跃疾病和并发症增加了这些患者的死亡风险.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 皮肤病学 皮肤病学
背景情况:
- 关于2019年新冠肺炎疾病 (COVID-19) 在自身免疫性牛肉性疾病 (AIBDs) 的结果的数据有限.
- 了解COVID-19对AIBD患者的影响对于临床管理至关重要.
研究的目的:
- 为了调查自身免疫性型疾病患者中COVID-19感染的频率和结果.
- 在这个患者群体中确定与COVID-19感染和死亡率相关的风险因素.
主要方法:
- 进行了一项基于调查的单中心观察性研究.
- 409名患有AIBD的患者完成了有关COVID-19感染和结果的电话调查.
- 数据是在2021年6月至10月期间收集的.
主要成果:
- 感染COVID-19的频率为12.2% (50/409),病例死亡率为18% (9/50).
- 在流行病后开始的瑞图西马布输注显著增加了COVID-19感染风险.
- 活跃的AIBD和并发症与COVID-19相关死亡率的增加有关.
结论:
- 利图西马布的使用与AIBD患者COVID-19感染的可能性更高有关.
- 高龄,活跃疾病和并发症是这一群体中COVID-19死亡率的风险因素.
- 需要与对照组进行进一步的研究,以确定相对风险.
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