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阿里索尔B23-酸盐在敏感化和挑战期间改善卵蛋白诱导的过敏喘
Ki-Hyuk Nam1, Dong-Soon Im1,2
1Department of Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02446, Republic of Korea.
Biomolecules & therapeutics
|June 15, 2023
概括
来自Alisma orientale的阿里索尔B23酸盐 (AB23Ac) 有效地治疗小鼠过敏性喘. 这种化合物降低了呼吸道炎症和免疫细胞活性,这表明喘患者的潜在治疗益处.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 传统医学的传统医学.
背景情况:
- 阿里斯玛东方根茎是一种东亚传统的治疗脏疾病的药物.
- 甲醇提取物显示过敏抑制,阿里索尔B23-乙酸盐 (AB23Ac) 是最强大的烯.
- 针对过敏性喘的AB23Ac的疗效仍未得到研究.
研究的目的:
- 在卵胺诱导过敏喘小鼠模型中评估阿里索尔B23酸盐 (AB23Ac) 的体内疗效.
- 调查AB23Ac潜在抗喘作用背后的机制.
主要方法:
- 使用了一种卵素 (OVA) 诱导的过敏喘小鼠模型 (BALB/c).
- AB23Ac是在OVA敏感和/或挑战之前进行的.
- 评估了乳腺细胞脱粒化,肺抵抗,免疫细胞计数,炎症性细胞因子,PAS染色和脏氨酸激酶 (Syk) 结合.
主要成果:
- AB23Ac以剂量依赖的方式抑制了抗原诱导的大细胞脱粒化.
- 服用AB23Ac显著降低了肺抵抗,免疫细胞透和周围支气管/周周血管炎症.
- AB23Ac降低了炎症性细胞因子水平 (Th1 / Th2 / Th17) 和肺中的杯状细胞增生 (PAS染色细胞).
- 在分析中,发现AB23Ac与 tyrosine kinase (Syk) 紧密结合.
结论:
- 阿里索尔B23酸盐 (AB23Ac) 在小鼠模型中显示出显著的疗效,可以改善过敏性喘.
- AB23Ac通过在敏感化过程中抑制树突细胞的免疫反应,在挑战过程中抑制巨细胞的免疫反应而起作用.
- 该化合物的与腺氨酸激酶 (Syk) 的相互作用可能有助于其治疗作用.
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