基于光学纳米生物传感器的治疗点检测心血管疾病生物标志物
Tharmaraj Vairaperumal1, Chih-Chia Huang2,3, Ping-Yen Liu1,4
1Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan, ROC.
ACS applied bio materials
|June 15, 2023
概括
光学纳米生物传感器为心血管疾病的心脏生物标志物提供了快速,灵敏的检测. 本综述强调了用于早期诊断和临床检测的先进光学纳米生物传感器平台.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 分析化学 分析化学
背景情况:
- 心血管疾病 (CVD) 构成了全球重大健康挑战,需要准确及时诊断.
- 早期发现心脏生物标志物对于有效管理和个性化治疗策略至关重要.
- 对于心脏生物标志物的传统诊断方法通常面临速度,灵敏度和可访问性的限制.
研究的目的:
- 审查最近 (过去五年) 光学纳米生物传感器方法在心血管疾病生物标志物检测方面的进展.
- 根据光学信号读数对这些纳米生物传感器进行分类.
- 为CVD诊断提供光学纳米生物传感器平台所涉及的设计,材料和机制的全面概述.
主要方法:
- 在过去五年中报告的关于心脏生物标志物的光学纳米生物传感器应用的文献综述.
- 基于光学信号检测原则的纳米生物传感器的分类.
- 详细讨论生物标记物分类,传感器设计,纳米材料,生物受体,功能化,测试类型和传感机制.
主要成果:
- 光学纳米生物传感器提供快速,高度选择性和灵敏的心脏生物标志物的检测.
- 这些平台提供了诸如易于监控,低成本,广泛检测范围和高灵敏度等优势.
- 使用不同的读取技术的各种光学纳米生物传感器系统已被开发用于CVD生物标志物检测.
结论:
- 光学纳米生物传感器平台代表了对心血管疾病生物标志物的临床检测 (PoCT) 的有前途技术.
- 审查的技术显示了低检测极限和改进诊断能力的潜力.
- 预计光学纳米生物传感器的持续开发将提高心血管疾病的早期诊断和管理.
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