抗生素降低了波西洛波拉珊瑚相关细菌的多样性,降低了全生物体的氧气消耗,并激活了免疫基因表达
Michael T Connelly1, Grace Snyder1, Ana M Palacio-Castro2,3
1Department of Marine Biology and Ecology, University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science, Miami, Florida, USA.
Molecular ecology
|June 15, 2023
概括
抗生素治疗破坏了珊瑚细菌,减少了全生物体的氧气消耗,并激活了珊瑚的免疫力. 这突显了本地珊瑚相关细菌在维持珊瑚健康和共生中的关键作用.
科学领域:
- 海洋生物学 海洋生物学
- 微生物生态学 微生物生态学
- 珊瑚礁科学珊瑚礁科学
背景情况:
- 珊瑚与微生物的相互作用对于全生物体的健康至关重要.
- 了解细菌的作用需要实验操作.
- 珊瑚相关细菌影响营养循环和病原体防御.
研究的目的:
- 调查抗生素诱导的细菌社区破坏对珊瑚健康的影响.
- 评估在细菌操纵后珊瑚生理和基因表达的变化.
- 建立未来珊瑚共生实验的基线.
主要方法:
- 用于破坏波西洛波拉珊瑚中的细菌群落的抗生素 (安皮西林,链杆菌素,西普罗夫洛克萨).
- 测量了Symbiodiniaceae的光化学效率和全生物体的氧气消耗.
- 分析了细菌社区组成和珊瑚基因表达 (RNAseq).
主要成果:
- 抗生素改变了细菌社区结构,减少了多样性.
- 珊瑚的氧气消耗减少,而Symbiodiniaceae的光合作用没有受到影响.
- 宿主免疫力和应激反应基因在代谢功能的牺牲下得到了上调.
结论:
- 破坏本地珊瑚细菌会对全息生物健康产生负面影响.
- 与珊瑚相关的细菌对于维持珊瑚生理和功能至关重要.
- 实验性减少细菌多样性是未来共生研究的一个可行的方法.
相关概念视频
Gene Regulation in Microbial Communities: Quorum Sensing
50
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
50
Antibiotic Selection
54.8K
Overview
54.8K
Antimicrobial Effectiveness
98
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
98
Development of Antibiotic Resistance
48
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
48
Diversity of Protists IV
49
Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
49
Antimicrobial Proteins
1.1K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.1K


