布罗利祖马布相关的慢性鼻炎:一个新的内型和管理考虑
Taylor C Standiford1, Neil N Patel1, Amritpal Singh1
1Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head & Neck Surgery, University of California, San Francisco, California, USA.
International forum of allergy & rhinology
|June 15, 2023
概括
布罗利祖马布治疗可以增加患者的鼻鼻炎症. 在carboxymethylcellulose中局部用triamcinolone为这种副作用提供了潜在的治疗方法,改善了患者的管理.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 布罗利祖马布是一种免疫检查点抑制剂,用于癌症治疗.
- 免疫相关不良事件 (irAEs) 是已知的免疫治疗并发症.
- 上鼻炎是一种报告不足的irAE.
研究的目的:
- 在接受 pembrolizumab 治疗的患者中调查鼻炎症的发生率.
- 为了评估局部三诺在炭甲基纤维素治疗这种疾病的疗效.
主要方法:
- 对用 pembrolizumab 治疗的患者的回顾性图表审查.
- 对鼻症状和内镜检查结果的评估.
- 分析局部用氨的治疗结果.
主要成果:
- 接受 pembrolizumab 治疗的患者中有很大一部分患有鼻炎症.
- 在carboxymethylcellulose中的局部triamcinolone显示在鼻腔症状和炎症的改善.
结论:
- 布罗利祖马布治疗与鼻炎炎症的风险增加有关.
- 碳氧甲基纤维素中的局部三诺是一种有效的治疗选择,用于控制这种副作用.
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