在接受化疗的年轻癌症幸存者身上留下的原始毛囊
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Accurate Follicle Enumeration in Adult Mouse Ovaries
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Nana Ogino1, Yu Wakimoto1, Kohei Nakagawa1
1Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
The journal of obstetrics and gynaecology research
|June 15, 2023
概括
化疗会损害卵巢储备,影响生育能力的保护. 虽然抗穆勒尔激素水平可能不能完全反映化疗后的原始卵泡数量,但卵巢组织冷保存仍然是一个可行的选择.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 妇科病理学 妇科病理学
背景情况:
- 卵巢组织冷保存 (OTC) 对于接受化疗的癌症患者的生育能力保护至关重要.
- 血清抗穆勒尔激素 (AMH) 是卵巢储备的标志物,但其与化疗后的卵泡数的相关性尚不确定.
- 化疗对不同卵巢卵泡发育阶段的具体影响需要澄清.
研究的目的:
- 为了研究血清AMH水平和化疗后原始毛囊密度之间的关联.
- 为了确定哪个卵巢卵泡发育阶段在OTC前受到化疗的影响最大.
主要方法:
- 从33名接受OTC治疗的患者的卵巢组织组织学检查,分为化疗 (n=22) 和非化疗 (n=11) 组.
- 评估化疗诱导的病理性卵巢损伤和卵巢体积的估计.
- 对不同发育阶段的毛囊数量进行比较,以群体之间原始毛囊的百分比计算,并分析AMH水平与原始毛囊密度的比较.
主要成果:
- 与对照组相比,接受化疗的患者的血清AMH水平,卵巢体积和发育的卵泡密度显著降低.
- 血清AMH水平与原始卵泡密度相关,仅在非化疗组.
- 化疗显著减少了初级和二级毛囊的数量,但并没有减少原始毛囊.
结论:
- 化疗会导致卵巢损伤和主要和次要卵泡的显著损失,但保留了大量的原始卵泡.
- 血清AMH水平可能不准确地反映化疗后的原始卵泡储备.
- 由于原始毛囊的保存,OTC仍然是癌症患者受支持的生育保护策略.
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