在老年人心房动:一个基于人口的队列研究中使用静止素和中风率
Bisan Shweikialrefaee1, Dennis T Ko1,2,3,4, Jiming Fang2
1Department of Medicine University of Toronto Toronto Ontario Canada.
Journal of the American Heart Association
|June 15, 2023
概括
立方体使用显著降低了心房动 (AF) 患者中风风险. 控制胆固醇,特别是LDL,对于预防这一群体中风至关重要.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 动脉样硬化疾病是心房动 (AF) 患者不良事件的主要危险因素.
- 在AF中使用他类药物和中风发病率之间的关系需要进一步阐明.
研究的目的:
- 量化他类药物使用与心房动 (AF) 患者中风率之间的关联.
主要方法:
- 一项以人口为基础的回顾性队列研究,对261,659名年龄≥66岁的AF患者进行了加拿大安大略省的AF研究 (2009-2019).
- 使用因果特异性危险回归来评估他类药物使用率和中风率,并根据脂质水平调整二级模型.
- 调整了多种临床因素和抗凝剂作为随时间变化的共同变量.
主要成果:
- 达丁类药物的使用与中风率降低有关 (调整后的危险比:0.83;95% CI,0.77-0.88).
- 这种关联在调整脂质水平后仍然存在 (调整HR:0.87;95%CI,0.78-0.97).
- 较高的低密度脂蛋白 (LDL) 水平 (>1.5 mmol/L) 与中风发生率的增加相关.
结论:
- 类固醇药物治疗与AF患者中风发病率降低有关.
- 有效地管理血管风险因素,包括增加的LDL胆固醇,对于预防AF中风至关重要.
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