不同的局部雌激素疗法为GSM量身定制的方法
R E Nappi1,2, L Tiranini1,2, E Martini2
1Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
概括
局部雌激素治疗 (LET) 有效地治疗更年期 (GSM) 症状的生殖泌尿综合征. 患者的偏好和及时治疗是管理 vulvovaginal 缩 (VVA) 和改善生活质量的关键.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 老年医学 老年医学
- 妇女健康 妇女健康
背景情况:
- 局部雌激素治疗 (LET) 是治疗与衰老和内分泌功能下降相关的泌尿器官症状的主要治疗方法.
- 不同的LET配方和分子提供可比的治疗结果.
- 低剂量的LET是标准的,确保系统吸收最小,并保持绝经后雌激素水平.
研究的目的:
- 审查更年期性泌尿生殖综合征 (GSM) 局部雌激素治疗的疗效和患者考虑.
- 突出LET采用的挑战,特别是严重的GSM症状和高风险人群,如乳腺癌幸存者 (BCS).
- 强调需要针对患者进行针对LET对生活质量,性功能和泌尿生殖系统健康的影响的研究.
主要方法:
- 关于局部雌激素治疗配方和分子的现有文献的审查.
- 分析治疗结果和患者对LET的满意度.
- 考虑特定的患者群体,包括乳腺癌幸存者 (BCS) 和服用芳酶抑制剂的患者.
主要成果:
- 多种LET配方 (药片,环,奶油等) 和分子 (雌醇,雌醇等) 的含量. 显示出类似的疗效.
- 患者的偏好是选择LET产品的一个重要因素.
- 对于严重的更年期性泌尿综合征 (GSM) 症状,延迟开始治疗是常见的,导致不满.
结论:
- 局部雌激素治疗 (LET) 对于管理更年期的生殖泌尿综合征 (GSM) 至关重要,包括 vulvovaginal 缩 (VVA).
- 解决患者的偏好和克服及时治疗的障碍对于改善结果至关重要.
- 需要进一步研究LET对生活质量和性功能的患者特异性影响,特别是在高危人群中.
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