成本效益分析和扩展治疗准入模型对转换到从约旦的参考Rituximab转换到Rituximab生物类似药的成本效益分析和扩展治疗准入模型
Hala H Halawah1, Nimer S Alkhatib1,2,3, Abdulaali R Almutairi4
1Al-Zaytoonah University of Jordan, Amman, Jordan.
Journal of medical economics
|June 15, 2023
概括
利图西马布生物仿制药在约旦提供了显著的成本节约和改善了患者的获取. 里克萨顿证明了每名患者最低的成本和最高的访问扩展,这使得它成为一个非常具有成本效益的选择.
科学领域:
- 药物经济学 药物经济学
- 卫生经济学 卫生经济学
- 瘤学 治疗学 治疗学
背景情况:
- 利图西马布是各种适应症的关键生物疗法.
- 生物类似药的引入为节省成本和扩大获取机会提供了机会.
- 评估生物类似药的成本效益对于国家卫生系统至关重要.
研究的目的:
- 评估与参考药物Rituximab相比,三种Rituximab生物类似药的成本效益和扩大患者获取.
- 从约旦国家卫生支付人的角度分析这些指标.
主要方法:
- 开发了一个为期一年的成本效益和扩展访问模型.
- 该模型模拟了从参考修复剂 (Mabthera) 到生物类似药 (Truxima,Rixathon,Tromax) 的转换.
- 关键指标包括每名患者的年度成本,头对头成本比较,患者访问,需要转换的数量 (NNC) 和支出.
主要成果:
- 里克萨松在六种适应症中显示出每名患者平均年费最低 (JOD2,860).
- 切换到Rixathon在RA和PV指示中实现了最高的患者访问率 (321%).
- 里克萨顿的NNC最低 (4名患者),为10名额外的患者提供了访问权限.
结论:
- 利图西马布生物仿制药在约旦所有已批准的适用性方面都节省了成本.
- 瑞克萨顿提供了最低的年度成本和最高的患者访问扩展.
- 里克萨顿是最具成本效益的rituximab选择,改善了获得治疗的机会.
关键词:
生物类似药物 生物类似药物在这里,我们可以看到H H H H H H.H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H5 H3 H5 H5 H5 H5 H3 H4 H5 H5 H6 H7 H8 H8 H8 H8 H8 H8 H8 H9 在线阅读更多H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51 H51我已经开始了,我已经开始了.第111章 这是什么?第115章 在这里约旦 约旦 约旦 约旦经济效率 经济效率 经济效率扩大了访问权限的扩大这就是Rituximab.相关概念视频
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
148
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
148
Bioequivalence: Overview
1.1K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
1.1K
Pharmacokinetic Models: Comparison and Selection Criterion
109
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
109
Renal Drug Clearance: Comparison Between Renal Excretion Methods
187
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
187


