在老年人中阻塞性睡眠呼吸暂停的全球患病率和相关因素:系统性审查和元分析研究
Tina Ghavami1, Mohsen Kazeminia1, Nassim Ahmadi2
1Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
概括
阻塞性睡眠呼吸暂停 (OSA) 影响全球35.9%的老年人. 关键的危险因素包括肥胖,BMI增加,心血管疾病和糖尿病,突出了有针对性的老年护理的需要.
科学领域:
- 老年学是一门学科.
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是老年人中普遍存在的疾病,但全球患病率数据和相关风险因素需要全面综合.
- 了解老年人群中OSA的流行病学对于制定有效的公共卫生策略和临床干预措施至关重要.
研究的目的:
- 进行系统性审查和元分析,以确定老年人中OSA的全球流行率.
- 确定与老年人群中OSA相关的关键因素.
主要方法:
- 在2021年6月之前,对多个数据库 (Embase,PubMed,Scopus,Web of Science,MagIran,SID) 进行了全面的搜索.
- 对39项涉及33353名老年人的研究进行了元分析,使用I2统计数据评估异质性,使用Egger回归截取方法评估出版偏差.
主要成果:
- 老年人中OSA的综合全球患病率为35.9% (95%CI:28.7%-43.8%),具有很高的异质性 (I2 = 98.81%).
- 亚组分析表明亚洲的患病率为37.0% (95%CI:22.4%-54.5%),尽管异质性仍然很高.
- OSA显著与肥胖,BMI增加,晚年,心血管疾病,糖尿病和白天嗜睡有关.
结论:
- 在老年人中,阻塞性睡眠呼吸暂停的全球患病率很大,并与几种并发症有关.
- 研究结果强调了在老年人诊断和管理中考虑OSA的重要性,特别是那些患有肥胖,心血管疾病或糖尿病的人.
- 研究中的高度异质性需要对结果进行谨慎的解释,并强调需要使用标准化方法进一步研究.
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