虚弱对八十多岁的冠状动脉外科手术患者大出血的影响
1Department of Cardiology, University of Health Sciences Gülhane Medicine School, Ankara City Hospital, Ankara, Turkey. keremozbek@dr.com.
European review for medical and pharmacological sciences
|June 15, 2023
概括
在接受皮肤冠状动脉干预 (PCI) 的老年患者中,脆弱性显著增加了重大出血风险. P2Y12抑制剂蒂卡格勒勒的使用与脆弱个体的高出血事件有关.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 临床医学 临床医学
背景情况:
- 穿皮冠状动脉干预 (PCI) 越来越多地在八十多岁的患者中进行.
- 虚弱,一个常见的衰老状况,与不良的健康结果有关.
- 了解脆弱性对PCI结果的影响对于这个不断增长的患者群体至关重要.
研究的目的:
- 在接受PCI的八十多岁患者中调查虚弱和重大出血事件之间的关联.
- 在这个人口群体中确定大出血的危险因素.
主要方法:
- 从两个土耳其医院的244名八十岁患者的回顾性分析.
- 患者被分为非虚弱 (临床虚弱度表 (CFS) 1-4) 或虚弱 (CFS 5-9).
- 包括重大出血,中风和全因死亡在内的结果在各组之间进行了比较.
主要成果:
- 严重出血发生在脆弱组 (20.4%) 与非脆弱组 (6.1%) 相比的频率明显增加.
- 虚弱的患者中风率 (15.9%对3.8%) 和全因死亡率 (27.4%对2.3%) 较高.
- 提卡格勒勒的使用在非脆弱组中更为普遍,但与脆弱患者的出血风险增加有关.
结论:
- 虚弱是八十多岁的病人进行PCI急性冠状动脉综合征的主要出血的独立预测器.
- 使用Ticagrelor,一种P2Y12抑制剂,可能会增加脆弱患者大出血的风险.
- 对脆弱性的临床评估对于管理PCI患者很重要.
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