在desmoid瘤中的编程细胞死亡联体-1 (PD-L1) 表达:一项回顾性研究
A N Toksoz Yildirim1, M Akyurek, E Okay
1Department of Pathology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. anuryldrm@gmail.com.
European review for medical and pharmacological sciences
|June 15, 2023
概括
德斯莫伊德瘤缺乏编程死亡配体1 (PD-L1) 表达,这表明抗PD-1/PD-L1疗法可能不有效. 然而,内淋巴细胞显示PD-L1阳性,需要进一步调查desmoid瘤治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 德斯莫伊德瘤是罕见的,局部具有侵略性的纤维细胞增殖,缺乏转移潜力,但复发率高.
- 在CTNNB1或APC基因的基因突变是特征的desmoid瘤.
- 虽然警等待适用于无症状病例,但对于具有高手术致病风险的症状患者来说,药物治疗是一种选择.
研究的目的:
- 评估计划死亡配体1 (PD-L1) 在desmoid瘤中的表达.
- 评估抗PD-1/PD-L1疗法在瘤治疗中的潜在疗效.
主要方法:
- 针对PD-L1表达的免疫组织化学染色是在从18名desmoid瘤患者的活检和切除样本上进行的.
- 使用Leica Bond®自动染色器进行抗体染色.
主要成果:
- 在18个样本中,没有任何一种desmoid瘤细胞表现出积极的PD-L1染色.
- 所有样本都含有内淋巴细胞.
- 其中五个样本在瘤内淋巴细胞中显示了阳性PD-L1染色.
结论:
- 在desmoid瘤细胞上缺乏PD-L1表达表明,抗PD-1/PD-L1治疗不太可能是有益的治疗策略.
- 具有PD-L1阳性的内淋巴细胞的存在表明,未来在desmoid瘤免疫疗法方面的研究可能成为一个潜在的领域.
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