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针对SARS-CoV-2的RdRp抑制剂的基于结构的药物设计

Kiran Shehzadi¹, Afsheen Saba¹, Mingjia Yu²

¹Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 10081, China.

Topics in current chemistry (Cham)

|June 15, 2023

概括

向病毒RNA依赖RNA聚合酶 (RdRp) 为开发新抗病毒药物提供了一个有前途的战略. 本综述分析了RdRp抑制剂,以帮助设计针对SARS-CoV-2和其他病毒感染的有效治疗方法.

科学领域:

病毒学病毒学
药物发现药物发现药物发现
结构生物学结构生物学

背景情况:

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 疫情迫切需要开发有效的治疗方法.
依赖RNA的RNA聚合酶 (RdRp) 对于病毒复制至关重要,也是抗病毒药物设计的关键标.

研究的目的:

探索病毒RdRp的抑制作为治疗策略.
分析RdRp在病毒增殖中的结构信息.
总结报告的RdRp抑制剂的药特征和结构-活性关系 (SAR).

主要方法:

对病毒RdRp结构和功能研究的文献综述.
对已知RdRp抑制剂的药理模型和SAR数据的分析.
收集与RdRp抑制相关的结构信息.

主要成果:

由于其在病毒复制中的关键作用,RdRp是抗病毒药物开发的验证目标.
已经确定了抑制剂的特定药特征和SAR配置文件.
对RdRp的结构洞察力为基于结构的药物设计提供了基础.

结论:

病毒RdRp的抑制为对抗病毒感染提供了可行的方法,包括SARS-CoV-2.
了解RdRp抑制剂药和SAR对于合理的药物设计至关重要.
本次审查提供了有价值的信息,以推动新型抗病毒药物的开发.

关键词:

在 COVID-19 疫情中,RdRpp 在线阅读作为RdRp抑制剂的使用.这就是SARS-CoV-2病毒.治疗目标治疗目标

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