NK细胞指导癌症免疫治疗的前景方法
Abduladheem Turki Jalil1, Mohanad Ali Abdulhadi2, Farah A Al-Marzook3
1Department of Medical Laboratories Techniques, Al-Mustaqbal University College, Hilla, Babylon, Iraq. abedalazeem799@gmail.com.
Medical oncology (Northwood, London, England)
|June 15, 2023
概括
自然杀手 (NK) 细胞在癌症治疗中表现有前途,但在固体瘤中面临挑战. 重新编程瘤屏障可以增强单独或与其他治疗相结合的NK细胞基础免疫疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 细胞疗法细胞疗法
背景情况:
- 自然杀手 (NK) 细胞是具有抗癌细胞毒性功能的关键先天性免疫细胞.
- 它们在固体瘤中的治疗潜力受到瘤透问题和抑制性微环境的限制.
- 障碍物包括与癌症相关的肌瘤和支持瘤的免疫细胞,这些免疫细胞阻碍NK细胞的活动.
研究的目的:
- 审查克服NK细胞基癌症免疫治疗障碍的战略.
- 探索重编程瘤微环境的潜力,以提高NK细胞的疗效.
- 讨论基于NK的新型免疫疗法和组合方法的开发.
主要方法:
- 关于NK细胞生物学和癌症免疫治疗的当前文献的综述.
- 在实体瘤中抑制NK细胞的机制的分析.
- 检查针对瘤微环境和NK细胞功能的治疗策略.
主要成果:
- NK细胞的抗瘤活性受到瘤微环境中的因素显著影响.
- 克服这些抑制因素的策略对于有效的NK细胞治疗至关重要.
- 重新编程瘤屏障可以增强NK细胞透和细胞毒性功能.
结论:
- 操纵瘤障碍物具有显著的潜力,可以改善基于NK细胞的癌症治疗.
- NK细胞免疫疗法可以作为单一疗法或与其他疗法结合开发.
- 基于NK的新型免疫疗法可能是克服当前治疗局限性的结果.
相关概念视频
01:27Cytotoxic T Cells-mediated Immune Response
999
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
999
01:27Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
01:28Cells of the Innate Immune Response
1.8K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.8K
01:25Immune Surveillance by NK Cells and Phagocytes
1.5K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.5K
01:30Cancer Vaccines
434
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
434
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
209
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
209