从多个角度对促进cuproptosis的基因签名进行全癌症分析
Jincheng Ma1, Baocheng Gong1, Qiang Zhao2
1Tianjin Key Laboratory of Cancer Prevention and Therapy, Department of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer Tianjin, Hu Rd, Ti Yuan Bei, Hexi District-West Huan, Tianjin, 300060, People's Republic of China.
Clinical and experimental medicine
|June 15, 2023
概括
细胞亡是一种新的细胞死亡形式,在八种癌症中显示出有利的预后. 较高的cuproptosis分数与免疫细胞透率较低和ferroptosis增加相关,有助于预测患者的结果.
科学领域:
- 细胞生物学 细胞生物学
- 癌症研究 癌症研究
- 分子瘤学分子瘤学
背景情况:
- 细胞亡是一种新发现的编程细胞死亡形式.
- 七个基因已被确定为cuproptosis的关键调节者.
- 了解cuproptosis在癌症中的作用对于治疗开发至关重要.
研究的目的:
- 研究各种癌症中与cuproptosis相关的基因的表达,预后价值和突变状态.
- 分析cuproptosis活动与临床结果,免疫微环境和其他细胞死亡途径之间的关联.
- 开发基于cuproptosis状态的患者分层的新型分类和预测模型.
主要方法:
- 利用癌症基因组图谱 (TCGA) 数据库进行表达,预后和突变分析.
- 进行单个样本基因组丰富分析 (ssGSEA) 来计算cuproptosis分数.
- 进行了生存分析,途径丰富,免疫透分析,并构建了风险模型 (例如,LASSO Cox回归,名图).
主要成果:
- 杯症得分与八种TCGA癌症类型的良好预后有关.
- 高杯性得分组显示,与癌症相关的纤维细胞,B细胞,中性粒细胞和乳腺细胞的丰度降低.
- 在高cuproptosis得分组中观察到高铁灭活性.
- 新的分类和风险模型有效预测了特定癌症 (例如,脏脏清细胞癌,肝肝细胞癌) 的患者存活率.
结论:
- 质亡活动与癌症预后和瘤免疫微环境有显著的关联.
- 质亡可能与其他细胞死亡途径相互作用,特别是铁亡.
- 这些发现为进一步研究cuproptosis作为潜在的治疗标和生物标志物提供了基础.
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