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通过超直接途径和皮质脊髓导向参数建议编程亚thalamic核深度大脑刺激

Alba Segura-Amil^1,2, Andreas Nowacki¹, Ines Debove³

¹Department of Neurosurgery, University Hospital Bern, Bern, Switzerland.

Human brain mapping

|June 15, 2023

概括

这项研究开发了模型,以优化对帕金森病的深度大脑刺激 (DBS),通过准超直接途径 (HDP) 获得益处,并避免皮质脊髓管 (CST) 产生副作用.

科学领域:

神经科学是一个神经科学.
神经外科神经外科
生物医学工程生物医学工程

背景情况:

脑下核 (STN) 的深度大脑刺激 (DBS) 有效地治疗晚期帕金森病.
有益效应与超直接通路 (HDP) 刺激有关,而囊性副作用则源于皮质脊髓管 (CST) 激活.

研究的目的:

开发和验证患者特定的模型,以建议最佳的STN DBS刺激参数.
通过估计HDP激活 (治疗效果) 和CST激活 (副作用) 的值来指导DBS编程.

主要方法:

对20名患有双边STN DBS的帕金森病患者的回顾性分析.
特定于患者的概率性通道图以识别HDP和CST.
基于单极复查刺激参数的激活组织体积和途径流线的估计.

主要成果:

模型表明,在效果值时,HDP激活率为50%,在副作用值时,CST激活率为4%.
建议的刺激参数在交叉验证中显著优于随机建议.
建议误差的中位数为效果值1 mA,副作用值为1.5 mA.

结论:

开发的模型成功地建议基于HDP和CST激活的STN DBS设置.
管道引导的DBS编程有望优化帕金森病治疗.
需要进行前性研究来完善和实施这些通道导向编程策略.

关键词:

帕金森病的疾病.深度大脑刺激刺激大脑超直通路径是一种超直通路径.编程编程编程编程编程路径学路径学路径学路径学路径学

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