kynurenine 途径与急性 COVID-19 后客观认知障碍和 PASC 相关
Lucette A Cysique1,2, David Jakabek3, Sophia G Bracken2
1Peter Duncan Neuroscience Research Unit, St. Vincent's Centre for Applied Medical Research, Darlinghurst, New South Wales, Australia.
后急性COVID-19可能会导致认知障碍,与kynurenine通路有关. 这条途径提供了潜在的生物标志物和治疗认知功能障碍和COVID-19 (PASC) 后急性后果.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 后急性COVID-19或长期COVID,可能导致持续的认知障碍.
- 了解这些认知缺陷背后的生物学机制对于开发有效的干预措施至关重要.
研究的目的:
- 在后急性COVID-19患者中调查客观认知障碍的患病率和自然史.
- 探索认知功能,人口和临床因素,COVID-19 (PASC) 后急性后果和特定生物标志物之间的关系.
主要方法:
- 128名后急性COVID-19患者在诊断后的2,4个月和12个月接受了认知,嗅觉和心理健康评估.
- 评估了世卫组织定义的PASC,并测量了血液中细胞因子,神经生物标志物和 kynurenine路径 (KP) 代谢物.
- 使用全球缺陷评分 (GDS) 确定了客观认知障碍,回归模型分析了与时间和其他因素的关系.
主要成果:
- 轻度至中度认知障碍影响了16-26%的患者,其中46.5%的患者在12个月内至少出现一次认知障碍.
- 认知障碍与工作能力降低和客观测试的厌氧相关.
- 增加的KP代谢物,包括林酸和kynurenine,与较差的认知表现和较高的认知障碍可能性密切相关.
结论:
- kynurenine 途径与急性后COVID-19 认知障碍和PASC有关.
- 在长期的COVID中,KP代谢物作为认知功能障碍的潜在生物标志物.
- 准金氨酸途径可能为管理COVID-19的认知后果提供治疗途径.
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