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Updated: Jul 26, 2025

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

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C9orf72聚PR有助于p53脱离无素-蛋白酶体系统,并促进其稳定性

Fumin Yang1, Yacoubou Abdoul Razak Mahaman1, Bin Zhang1

  • 1Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Journal of neurochemistry
|June 15, 2023
PubMed
概括

来自C9orf72的聚氨酸-氨酸 (聚-PR) 通过稳定p53蛋白质,导致神经退行. 这项研究揭示了聚PR损害了无素-蛋白酶体系统,导致p53积累和C9-ALS/FTD的潜在治疗点.

关键词:
在C9orf72 PR中使用.在FTD/ALS中使用.mdm2 mdm2是什么意思在 p53 里,p53 是一个 p53 的类型.无处不在-蛋白酶体通路

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