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在皮质 - 基底腺通路中具有不同表示的对立学习可以发展痴迷 - 强迫循环
Reo Sato1, Kanji Shimomura1, Kenji Morita1,2
1Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
PLoS computational biology
|June 15, 2023
概括
计算机建模表明,基于模型和无模型系统的对手学习可能是强迫症 (OCD) 的基础. 这种双系统方法协调了强迫症中受损控制和记忆痕迹不平衡理论.
科学领域:
- 神经科学是一个神经科学.
- 计算精神病学是一种计算精神病学.
- 认知科学 认知科学
背景情况:
- 强迫症 (OCD) 与基于模型的控制能力受损有关.
- 以前的研究表明,强迫症涉及正负预测错误 (PE) 的差异性记忆痕迹.
研究的目的:
- 通过计算探索基于模型的控制受损与强迫症中改变的预测错误记忆之间的关系.
- 为了建模皮质-基底腺路径如何可能导致强迫症病理生理学.
主要方法:
- 开发了一种双系统计算代理,结合了基于继承者表示 (SR) (基于模型) 和基于个人表示 (IR) (无模型) 的系统.
- 在模拟痴迷-强迫循环的环境中模拟代理行为.
- 在两个阶段的决策任务中测试了该代理,比较了SR-only和SR+IR代理.
主要成果:
- 对于正 (SR) 和负 (IR) PEs,具有差异性学习率的双系统代理开发了一个痴迷-强迫循环.
- 与仅使用SR的药物相比,SR+IR药物表现出较低的基于模型的对照重量.
- 这个模型协调了基于模型的受损控制和OCD中的记忆痕迹不平衡理论.
结论:
- 基于模型 (SR) 和无模型 (IR) 系统之间的对立学习可能是痴迷强迫的基础.
- 这个框架为强迫症病理生理学提供了一个新的解释.
- 未来的工作可以探索对手学习的威胁/厌恶性电路对强迫症的更完整的模型.
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