植物病毒运动蛋白起源于果卷囊蛋白质
Anamarija Butkovic1, Valerian V Dolja2, Eugene V Koonin3
1Institut Pasteur, Université Paris Cité, CNRS UMR6047, Archaeal Virology Unit, Paris, France.
PLoS biology
|June 15, 2023
概括
植物病毒运动蛋白 (MPs) 从状蛋白 (CPs) 进化,共享同源结构域. 这一发现揭示了植物病毒的起源和传播.
科学领域:
- 植物病毒学 植物病毒学
- 分子进化是分子进化的过程.
- 结构生物学是结构生物学.
背景情况:
- 植物病毒利用运动蛋白 (MP) 通过等离子体病毒在细胞之间传播.
- 30K超级家族代表了最大和最多样化的国会议员群体,对系统性病毒传播至关重要.
- 3万名国会议员的进化起源在很大程度上是未知的.
研究的目的:
- 为了研究植物病毒运动蛋白的30K超级家族的进化起源.
- 为了确定MP和其他病毒蛋白之间的同源结构域.
主要方法:
- 对30KMP和病毒囊蛋白 (CP) 的比较结构分析.
- 生物信息学分析以确定同源领域和进化关系.
主要成果:
- 30KMP的核心结构域与小RNA和DNA病毒CP的果卷域相同.
- 最接近的相似性是在30K的MP和CP之间发现的,来自Bromoviridae和Geminiviridae家族的病毒.
- 通过基因重复或CP的水平基因转移提出了MP进化的假设.
结论:
- 30KMPs可能源于体蛋白质,通过基因复制或横向获取在祖先植物病毒中.
- 随后的新功能化和横向基因在各种病毒之间传播,塑造了当前的植物病毒组.
- 这种进化途径凸显了病毒与宿主相互作用和病毒基因组进化的动态性质.
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