自可以防止在Mycobacterium结核菌感染期间早期的促炎反应和中性粒细胞的招募,而不会影响巨细胞中的病原体负担
Rachel L Kinsella1, Jacqueline M Kimmey1, Asya Smirnov1
1Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.
PLoS biology
|June 15, 2023
概括
肺免疫细胞中的ATG5蛋白控制结核病期间的中性粒细胞炎症. 它的缺失会增加有害的炎症反应,影响疾病的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 微生物学 微生物学
背景情况:
- 结核病 (TB) 的结果取决于对Mycobacterium tuberculosis (M.tb) 的免疫反应.
- 中性线性炎症与结核病的预后不佳有关,需要严格监管.
- 一种自蛋白ATG5对于天生的免疫细胞来控制M.tb诱导的炎症和促进生存至关重要,但它在中性粒细胞招募中的确切作用尚不清楚.
研究的目的:
- 研究特定的先天性免疫细胞,需要ATG5来控制M.tb感染期间的中性粒细胞招募.
- 阐明ATG5在M.tb感染的背景下调节炎症的机制.
主要方法:
- 使用了在特定细胞类型中有条件删除Atg5的小鼠模型.
- 分析了免疫细胞种群,细胞因子和化学因子的产生,以及肺部的M.tb负担.
- 评估了自取决于自的途径的作用,包括菌,LC3相关的细胞分裂和炎症酶激活.
主要成果:
- 在CD11c+细胞 (肺巨细胞和树突细胞) 中需要ATG5,以限制促炎性细胞因子和化学因子的产生,从而控制中性粒细胞的招募.
- 这种ATG5的功能依赖于自,但独立于线粒,LC3相关的细胞分裂和炎症酶激活.
- 在先天免疫细胞中ATG5的损失导致增强的促炎性细胞因子产生和早期TH17反应,而不会改变巨细胞中的M.tb负担.
结论:
- 肺巨细胞和树突细胞中的ATG5在抑制与M.tb控制不良相关的炎症反应中发挥着关键作用.
- 揭示了先天免疫细胞中自蛋白的新功能,用于调节结核病期间的炎症.
- 突出了ATG5介导的中性粒细胞驱动炎症调节作为结核病的潜在治疗点.
相关概念视频
Autophagy
4.4K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.4K
Defense Against Bacterial Pathogens
1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Pulmonary Tuberculosis II
281
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
281
Inflammatory Response
2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K
Immune Surveillance by NK Cells and Phagocytes
1.5K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.5K
Phagocytosis of Apoptotic Cells
3.9K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Normal cells contain receptors that prevent them from being recognized...
3.9K


