综合评估与多发性硬化症相关的疲劳,特别关注疲劳性
Nicolas Royer1, Callum G Brownstein1, Djahid Kennouche1
1Univ Lyon, UJM-Saint-Etienne, Inter-university Laboratory of Human Movement Biology, Saint-Etienne, FRANCE.
Medicine and science in sports and exercise
|June 15, 2023
概括
与疲劳不大的人相比,患有多发性硬化症 (MS) 的高疲劳患者在运动期间表现出更大的神经肌肉疲劳和感知到的劳动力. 这种增加的疲劳性有助于MS中致残的疲劳症状.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 运动生理学 运动生理学
背景情况:
- 疲劳是多发性硬化症 (MS) 的普遍和衰弱症状,影响55-78%的患者.
- 与MS相关的疲劳的根本原因尚未完全理解,但增加的神经肌肉疲劳性可能起着重要作用.
研究的目的:
- 研究与MS (PwMS) 患者疲劳相关的生理和心理社会因素.
- 专门研究在动态运动任务期间与MS相关的疲劳和神经肌肉疲劳之间的关系.
主要方法:
- 招募了42个复发性缓解性PwMS和20个健康对照.
- 在逐步循环到任务失败期间,使用磁性和神经刺激评估最大自愿收缩 (MVC) 扭矩,感知力度和中央/外围参数.
- 根据经过验证的问卷,PwMS根据高 (HF) 和低 (LF) 疲劳组进行分类.
主要成果:
- 在疲劳性运动期间,高压组在MVC扭矩 (-15.7%) 的下降明显大于LF组 (-5.9%).
- 高频组报告了更高的感知力度,同时有更大的扭矩损失.
- 心理社会因素,包括抑郁和生活质量,在HF组显著恶化.
结论:
- 在高疲劳的PwMS中,表现较强的疲劳性显而易见.
- 增加的神经肌肉疲劳可能会导致更高的感知劳动和一些PwMS体验的致残疲劳.
- 这些发现为多发性硬化症中疲劳和疲劳性之间的复杂相互作用提供了新的见解.
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