在小的副耳器官中,前素和与神经递质相关的分子的表达模式
Md Shahriar Hasan Sohel1, Yasuro Atoji2, Sawa Onouchi2
1Laboratory of Veterinary Anatomy, Joint Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Tissue & cell
|June 15, 2023
概括
小的副膜器官 (PTO) 与前体毛细胞具有同源性,而不是听觉毛细胞. 这一发现有助于理解鸟类感官器官的功能和发育.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 比较解剖学的比较解剖学
背景情况:
- 鸟类的副耳膜器官 (PTO) 是一种中耳结构,具有毛细胞和来自生殖腺的内化.
- 它的感觉功能和相对于其他前庭听觉器官的细胞特征仍然不完全理解.
研究的目的:
- 为了研究鸟类PTO毛细胞和前庭毛细胞之间的组织化学相似性.
- 将PTO毛细胞的分子表达特征与前庭和听觉毛细胞的分子表达特征进行比较.
主要方法:
- 在现场杂交被用来检查0日产后小PTO和生殖腺的关键分子的表达.
- 分析的基因包括前素,GPR37/GPR37L1,vGluT2/vGluT3,nAChRα9和GAD65/GAD67.7等.
主要成果:
- 在PTO毛细胞,支细胞和生殖腺中检测到prosaposin mRNA.
- 在PTO毛细胞中发现了膀性谷氨酸转运体3 (vGluT3) mRNA.
- 尼古丁乙胆受体子单元α9 (nAChRα9) mRNA存在于PTO毛细胞的一个子集中.
结论:
- 小中PTO毛细胞的分子表达模式更像是前庭毛细胞,而不是听觉毛细胞.
- 这表明,在鸟类中,PTO与前体系统之间存在潜在的功能或发育联系.
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