相关实验视频

Updated: Jul 26, 2025

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

动态对比增强的MRI用于表征原发性上皮卵巢癌中的血管生成:一项探索性研究

Auni Lindgren¹, Maarit Anttila¹, Otso Arponen²

¹Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland; University of Eastern Finland, Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, Obstetrics and Gynaecology, Kuopio, Finland.

European journal of radiology

|June 15, 2023

概括

动态对比增强型MRI (DCE-MRI) perfusion 参数显示出在上皮卵巢癌 (EOC) 中评估瘤血管生成的前景. 这些成像生物标志物与血管内皮生长因子 (VEGF) 和微血管密度 (MVD) 相相关,有助于癌症评估.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
生物标志物生物标志物

背景情况:

血管新生对于瘤生长至关重要,但瘤组织中缺乏已知的成像生物标志物.
评估瘤血管生成对于了解上皮卵巢癌 (EOC) 的进展和治疗反应至关重要.

研究的目的:

评估半定量和药物动力学动态对比增强MRI (DCE-MRI) perfusion 参数作为EOC中的血管生成成像生物标志物的潜力.
为了将DCE-MRI参数与已确定的血管生成标记物如VEGF,VEGFR-2和微血管密度 (MVD) 相关联.

主要方法:

一项前性研究,涉及38名初级EOC患者,在手术前接受DCE-MRI.
使用大 (L-ROI) 和小 (S-ROI) 感兴趣区域对DCE-MRI半定量和药物动力学参数的分析.
对瘤组织进行VEGF,VEGFR-2表达和微血管密度 (MVD) 的免疫组织化学分析.

主要成果:

在VEGF表达和DCE-MRI参数 (Ktrans,Ve,Vp) 之间观察到逆相关性.
较高的VEGFR-2表达与较低的Ktrans和Ve值相关.
微血管密度 (MVD) 和微血管数量与DCE-MRI参数 (AUC,峰值,WashIn) 有正相关.

结论:

DCE-MRI输液参数显示了与VEGF和VEGFR-2表达和EOC中的MVD的显著相关性.
半定量和药物动力学DCE-MRI参数都显示出作为评估EOC中的血管生成的非侵入性成像生物标志物的潜力.

关键词:

血管新生的产生.动态对比增强磁共振成像表面性卵巢癌卵巢癌磁共振成像是一种磁共振成像技术.微型船只的使用方法血管内皮生长因子A 血管内皮生长因子A

更多相关视频

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

相关概念视频

Imaging Studies VII: Vascular Imaging

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...