在 brojler中,活跃的内葡萄糖吸收的发展
Mikako Shibata1, Tatsuyuki Takahashi1, Takaharu Kozakai2
1Laboratory of Animal Metabolism and Function, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan.
Poultry science
|June 15, 2023
概括
肉的肠道葡萄糖吸收随着年龄的增长而降低,这是由于/葡萄糖共运输体1 (SGLT1) 的敏感性和离子透性降低,尽管肠道发育. 这影响了营养利用和料开发战略.
科学领域:
- 动物生理学 动物生理学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 肉的快速生长需要了解肠道的营养吸收.
- 关于在肉生长期间对肠道葡萄糖吸收调节的现有研究是有限的,往往是矛盾的.
研究的目的:
- 为了研究肠道葡萄糖吸收的调节机制在肉在成长.
- 为了分析葡萄糖吸收,运输和相关基因表达随着年龄的变化.
主要方法:
- 口服葡萄糖测量和血糖监测.
- 使用埃文斯蓝色进行肠道透性评估.
- 在体外试验中,使用透的肠袋和Ussing腔室进行了研究.
- 对葡萄糖载体和细胞结点的基因表达分析.
- 扫描电子显微镜用于肠道形态学.
主要成果:
- 年长的 (5周) 与年轻的 (1周) 相比,显示出更高的血糖峰值和曲线下的面积.
- 在老中,肠道葡萄糖的吸收和阴中的电生成运输减少.
- /葡萄糖共运输体1 (SGLT1) 抑制剂 (化) 影响了年轻的葡萄糖运输,但不影响老.
- 组织导电性下降,老的尾小扩大,表明肠道过度发育.
结论:
- 尽管肠道的整体发育,肉表现出与年龄相比降低了内葡萄糖的吸收.
- 降低SGLT1敏感性和较低的离子透性有助于降低老肉的葡萄糖吸收.
- 研究结果为制定肉的有针对性的营养策略和新料配方提供了洞察力.
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