聚合物介导和超声波辅助的ropivacaine的结晶:晶体生长和形态调节的调节
Yan Wang1, Huixiang Zhang1, Lun Cai1
1School of Pharmaceutical Sciences (Shandong Analysis and Testing Center), Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, PR China.
Ultrasonics sonochemistry
|June 15, 2023
概括
聚烯 (PVP) 和超声波改变了罗皮瓦卡因的晶体形状,将针状结构转化为可控制的块状或米状晶体. 这项研究提高了对难溶性药物的结晶核和生长的理解.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 制药科学 制药科学
背景情况:
- 罗皮瓦卡因是一种水溶性较差的药物,通常形成难以控制的针状晶体.
- 无法控制的晶体形态可以对药物的溶解性,生物可用性和配方疗效产生负面影响.
研究的目的:
- 为了修改罗皮瓦卡因的晶体形状和大小.
- 研究聚合物添加剂和超声波对罗皮瓦卡因晶体核和生长的影响.
- 为了阐明形态进化背后的机制.
主要方法:
- 使用聚烯 (PVP) 作为聚合物添加剂的结晶实验.
- 超声波辅助结晶,具有不同的超声波参数和添加剂度.
- 扫描电子显微镜 (SEM) 和原子力显微镜 (AFM) 用于表面和形态分析.
- 分子动力学模拟用于研究聚合物-晶体相互作用和添加剂移动性.
主要成果:
- 聚烯利 (PVP) 诱导了类似块的罗皮瓦卡因晶体的形成.
- 超声波处理,特别是长时间处理,产生了板状晶体,面积比较小.
- 结合PVP和超声波的使用,产生了大米形晶体,平均颗粒大小显著降低.
- PVP表现出强大的核化和生长抑制特性.
结论:
- 聚合物添加剂如PVP和超声波是控制罗皮瓦卡因晶体形态和大小的有效工具.
- 该研究提出了一种由PVP和超声波驱动的形态进化的机制.
- 研究结果为优化难溶药物的结晶过程提供了洞察力,以改善其物理化学特性.
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