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Updated: Jul 26, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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ROTACs利用信号不合格的R-脊髓蛋白进行向蛋白质降解

Rui Sun1, Zibo Meng2, Hyeyoon Lee1

  • 1Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany.

Cell chemical biology
|June 15, 2023
PubMed
概括

研究人员开发了ROTACs,新型双特异性R-脊髓蛋白 (RSPO) 嵌合体,以降解PD-L1.1等细胞表面蛋白质. 这项新技术有效地准跨膜蛋白,为癌症治疗提供了一个有前途的治疗策略.

关键词:
在LYTAC中,我们可以使用LYTAC在PD-L1中.这就是PROTAC.在R-spondin的使用中.RNF43 RNF43是什么意思在ZNRF3中,lysosome 溶解酶体是如何形成的蛋白质降解 蛋白质降解通过膜的E3结合酶.

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