长期噪音,极低频电磁场和轮班工作暴露对肝酶的独立,修饰和相互作用的影响
Masoud Khosravipour1, Masoud Ghanbari Kakavandi2, Faramarz Gharagozlou2
1Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Environmental pollution (Barking, Essex : 1987)
|June 15, 2023
概括
长期暴露在工作场所的噪音,极低频电磁场 (ELF-EMF) 和旋转的夜班显著改变了肝酶 (AST,ALT). 这些因素之间的相互作用也影响了热电厂工人的肝酶水平.
科学领域:
- 职业健康 职业健康 职业健康
- 环境健康 环境健康
- 生物化学 生物化学
背景情况:
- 工作场所暴露的噪音,极低频电磁场 (ELF-EMF) 和轮班工作在热电厂等行业中普遍存在.
- 对特定生物标志物 (如肝酶) 的联合暴露的长期健康影响需要进一步研究.
- 了解这些影响对于制定有针对性的职业健康战略至关重要.
研究的目的:
- 量化长期噪音,ELF-EMF和轮班工作对男性热电厂工人的肝酶 (AST,ALT) 的独立,修饰和相互作用影响.
- 分析不同频段的噪声暴露及其与肝脏酶变化的关联.
- 评估轮流夜班与固定白天班对肝酶水平的影响.
主要方法:
- 一项为期四年的反复测量研究 (2016-2020年) 涉及热电厂的男性工人.
- 测量8小时相当的声压水平 (Leq),使用Z,A和C权重对八度频段的频率和8小时时间权重平均ELF-EMF水平.
- 确定轮班工作计划 (3轮夜 vs. 固定日) 和分析空腹血液样本的AST和ALT水平,使用引导混合效应线性回归模型.
主要成果:
- 增加的噪声暴露 (每10dB) 与AST和ALT水平的更高百分比变化显著相关,特别是LAeq.
- 较高的ELF-EMF暴露 (每1毫克) 与AST和ALT水平的增加有显著联系.
- 三轮夜班工作与AST和ALT的变化有显著的关联,特别是与ELF-EMF相结合时. 在噪音,ELF-EMF和轮班工作中观察到显著的相互作用效应,对于这两种酶.
结论:
- 长期接触噪音,ELF-EMF和3轮夜班的工作与肝酶水平 (AST,ALT) 的变化有显著关联.
- 这项研究强调了这些联合暴露对肝功能的潜在协同或相互作用的不良影响.
- 调查结果强调需要全面的职业健康干预措施,以应对多种工作场所压力因素.
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