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Updated: Jul 26, 2025

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纳米药物配方的演变,用于有针对性的输送和受控释放

Sanyogitta Puri1, Mariarosa Mazza1, Gourgopal Roy2

  • 1Advanced Drug Delivery, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.

Advanced drug delivery reviews
|June 15, 2023
PubMed
概括

纳米颗粒药物载体正在推进基因组医学,通过使核酸输送用于治疗性蛋白质调制. 关键的生物测试和表征对于它们的临床转化和商业发展至关重要.

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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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