在一项全国性的注册研究中,住院的固体器官移植接受者中的COVID-19在全国注册研究中
Víctor Moreno-Torres1, María Martínez-Urbistondo2, Jorge Calderón-Parra2
1Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain; Universidad Internacional de La Rioja (UNIR) Health Sciences School, Madrid, Spain.
概括
在西班牙,固体器官移植接受者 (SOTR) 中的COVID-19死亡率整体上没有增加. 然而,肺移植接受者经历的结果明显更差,强调了需要有针对性的管理策略.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 潜在的免疫缺陷可能会使COVID-19的呈现和死亡率恶化.
- 固体器官移植接受者 (SOTR) 是易受传染病影响的人群.
- 在SOTR中评估COVID-19的结果对于了解疾病影响至关重要.
研究的目的:
- 评估在西班牙住院的固体器官移植接受者 (SOTR) 中COVID-19的死亡风险.
- 为了比较SOTR和普通人口之间的COVID-19死亡率.
- 确定与死亡率增加相关的特定移植类型.
主要方法:
- 2020年西班牙成人COVID-19住院病例的全国性,回顾性,观察性研究.
- 数据来源于国家医院出院登记处,使用ICD-10代码.
- 患者根据实体器官移植 (SOT) 状态进行了分层.
主要成果:
- 在117,694名住院成年人中,有491人是SOTR (390人是脏,59人是肝脏,27人是肺部,19人是心脏).
- 经过调整后,SOTR总体死亡率为13.8%,不显著高于一般人口 (OR=0.79).
- 肺移植接受者死亡率显著高 (OR=3.26),被确定为最强的预后因素 (OR=5.12).
结论:
- 2020年西班牙SOTR的COVID-19死亡率与普通人口相比,肺移植接受者除外.
- 肺移植接受者代表了COVID-19死亡率高风险组.
- 对于COVID-19肺移植接受者的最佳管理策略需要专注的关注.
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