对抗结核病药物的第一个住院疗效研究2a阶段的翻译预测

Jacqueline P Ernest1,2, Janice Jia Ni Goh1,2, Natasha Strydom1,2

  • 1Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.

概括

使用临床前数据预测结核病药物疗效可以加速开发. 一个新的模型从小鼠的药理动力学-药理动力学数据准确预测临床早期杀菌活性 (EBA),可能取代昂贵的2a期试验.

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