化功能化的纤维素作为反应性吸收剂,用于捕获和保留与慢性伤口相关的聚胺气味分子
Jianchuan Wen1, Menal Almurani1, Pengyuan Liu1
1Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, United States of America.
Carbohydrate polymers
|June 15, 2023
概括
基功能化纤维素 (AFC) 为控制慢性伤口气味提供了一种新的反应性吸附策略. 在保持气味分子方面,AFC在木炭上表现优越,这表明医疗保健结果有所改善.
科学领域:
- 生物材料科学 生物材料科学
- 织品化学 织品化学
- 伤口护理技术 伤口护理技术
背景情况:
- 慢性伤口通常会产生不愉快的气味,原因是基于聚胺的化合物.
- 目前的气味控制方法,如木炭,依赖于物理吸附,并有局限性.
- 在伤口护理中,开发先进的材料以有效地控制气味至关重要.
研究的目的:
- 合成和表征阿尔代功能化纤维素 (AFC) 作为一种反应性吸附剂.
- 为了评估AFC在控制基于聚胺的气味方面的有效性,使用尸体作为模型.
- 为了比较AFC与木炭的性能,用于慢性伤口气味管理.
主要方法:
- 通过纤维素氧化与甲基酸盐合成的AFC.
- 使用希夫测试,FT-IR,UV-vis,CHN分析和ninhydrin测试进行表征.
- 使用LC/MS对尸体吸附/脱附的量化,并通过XTT试验评估生物相容性.
主要成果:
- 通过Schiff-base形成,AFC有效地与尸体发生反应,多次测试证实了这一点.
- 与木炭相比,AFC在相关度下表现出优异的吸收和明显更好的尸体保留.
- 结合的AFC和木炭显示了增强的和脱特性;AFC显示了良好的体外生物相容性.
结论:
- AFC介绍了一种有前途的反应性吸附策略,用于慢性伤口气味控制.
- AFC的化学反应和保留能力超过了传统的木炭吸附剂.
- 在慢性伤口管理中,AFC具有提高患者舒适度和医疗保健的潜力.
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